An antagonist of ERα that blocks 17β-estradiol-induced proliferation of drug-resistant cancer cell lines at concentrations ranging from 10 to 1

BHPI – 5 mg

Brand:
Cayman
CAS:
56632-39-4
Storage:
-20
UN-No:
Non-Hazardous - /

BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial, and ovarian cancer cell lines at concentrations ranging from 10 to 1,000 nM.{28679} It is effective in vivo, driving tumor regression in mice bearing MCF-7 xenografts at a dose of 15 mg/kg daily.{28679} BHPI specifically inhibits ERα-dependent gene expression and protein synthesis by activating the unfolded protein response in cells.{28679}  

 

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Description

An antagonist of ERα that blocks 17β-estradiol-induced proliferation of drug-resistant cancer cell lines at concentrations ranging from 10 to 1,000 nM; drives tumor regression in mice bearing MCF-7 xenografts; inhibits ERα-dependent protein synthesis by activating the unfolded protein response in cells

Formal name: 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one

Synonyms: 

Molecular weight: 331.4

CAS: 56632-39-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Multidrug Resistance||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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