A cell-permeable inhibitor of class IIa HDACs (IC50s = 126

TMP269 – 1 mg

Brand:
Cayman
CAS:
1314890-29-3
Storage:
-20
UN-No:
Non-Hazardous - /

While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling.{26846} Class IIa HDACs, which include HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology.{22864} TMP269 is a cell-permeable inhibitor of class IIa HDACs (IC50s = 126, 80, 36, and 19 nM for HDAC4, 5, 7, and 9, respectively).{28861} It contains a metal-binding group, trifluoromethyloxadiazole that confers selectivity for class IIa HDACs.{28861}  

 

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Description

A cell-permeable inhibitor of class IIa HDACs (IC50s = 126, 80, 36, and 19 nM for HDAC4, 5, 7, and 9, respectively)

Formal name: N-[[tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-benzamide

Synonyms: 

Molecular weight: 514.5

CAS: 1314890-29-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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