A PAD2 and PAD4 inhibitor (IC50s = 0.5-1 and 1-5 μM

YW3-56 (hydrochloride) (technical grade) – 5 mg

Brand:
Cayman
CAS:
2309756-20-3
Storage:
-20
UN-No:
De Minimis - 1230 / 3|6.1

YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).{28621} It inhibits the growth of U2OS osteosarcoma cells (IC50 = ~2.5 μM) in a p53-dependent manner via induction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.{39944}  

 

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Description

A PAD2 and PAD4 inhibitor (IC50s = 0.5-1 and 1-5 μM, respectively); inhibits the growth of U2OS osteosarcoma cells (IC50 = ~2.5 μM) in a p53-dependent manner; reduces tumor growth in a S-180 murine sarcoma tumor model at 10 mg/kg; inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model,

Formal name: N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide, monohydrochloride

Synonyms: 

Molecular weight: 530.5

CAS: 2309756-20-3

Purity: ≥80%

Formulation: A solution in methanol

Product Type|Biochemicals|Small Molecule Inhibitors|Deiminases||Research Area

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