A ferroptosis inhibitor; inhibits cell death induced by erastin (EC50 = 60 nM) and RSL3

Ferrostatin-1 – 5 mg

Brand:
Cayman
CAS:
347174-05-4
Storage:
-20
UN-No:
Non-Hazardous - /

Ferrostatin-1 is a ferroptosis inhibitor.{28856} It inhibits cell death induced by the ferroptosis inducers erastin (Item No. 17754; EC50 = 60 nM) and RSL3, but not by hydrogen peroxide, rotenone, or staurosporine, in HT-1080 cells when used at a concentration of 0.5 μM. Ferrostatin-1 (0.5 μM) inhibits erastin-induced production of reactive oxygen species (ROS) and lipid peroxidation in HT-1080 cells. It increases cell survival in cell-based models of Huntington’s disease, periventricular leukomalacia, and kidney proximal tubule damage in a concentration-dependent manner.{28857} Ferrostatin-1 (2 μM) inhibits cell death induced by L-glutamate in a rat organotypic hippocampal slice culture (OHSC) model.{28856} It also inhibits autooxidation of lipids by trapping peroxyl radicals.{28856,43395}  

 

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Description

A ferroptosis inhibitor; inhibits cell death induced by erastin (EC50 = 60 nM) and RSL3, but not by hydrogen peroxide, rotenone, or staurosporine, in HT-1080 cells at 0.5 μM; inhibits erastin-induced production of ROS and lipid peroxidation in HT-1080 cells at 0.5 μM; increases cell survival in cell-based models of Huntington’s disease, periventricular leukomalacia, and kidney proximal tubule damage; inhibits cell death induced by L-glutamate in a rat OHSC model at 2 μM; inhibits autooxidation of lipids by trapping peroxyl radicals`

Formal name: 3-amino-4-(cyclohexylamino)-benzoic acid, ethyl ester

Synonyms:  Fer-1

Molecular weight: 262.4

CAS: 347174-05-4

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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