A small molecule

Toceranib – 50 mg

Brand:
Cayman
CAS:
356068-94-5
Storage:
-20
UN-No:
Non-Hazardous - /

Toceranib is a small molecule, multi-targeted receptor tyrosine kinase inhibitor that is structurally related to sunitinib (Item No. 13159).{17826} It potently inhibits signaling through VEGFR, FGFR, PDGFR, and Kit.{17826} Moveover, toceranib blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death.{17826} It is active in vivo and is commonly used against solid tumors in dogs.{28879,28880}  

 

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Description

A small molecule, multi-targeted receptor tyrosine kinase inhibitor; blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death; active in vivo and commonly used against solid tumors in dogs

Formal name: 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide

Synonyms:  PHA 291639|SU11654

Molecular weight: 396.5

CAS: 356068-94-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|FGFR Family||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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