A verapamil derivative that dose-dependently blocks calcium uptake via Na+/Ca2+ exchange in diverse types of cells (Ki = 28 µM); also prevents calcium release from mitochondria induced by Ruthenium Red but not by uncouplers

YS-035 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
89805-39-0
Storage:
-20
UN-No:
Non-Hazardous - /

YS-035 is a verapamil derivative that dose-dependently blocks calcium uptake via Na+/Ca2+ exchange in diverse types of cells (Ki = 28 µM).{28773} It inhibits calcium uptake by muscle cells, brain synaptosomes, and kidney fibroblasts.{28773} YS-035 also prevents calcium release from mitochondria induced by Ruthenium Red but not by uncouplers, respiratory inhibitors, or a chelating agent.{28773} YS-035 is used to characterize the role of calcium currents in smooth muscle and neuronal electrophysiology.{28774,28775}  

 

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Description

A verapamil derivative that dose-dependently blocks calcium uptake via Na+/Ca2+ exchange in diverse types of cells (Ki = 28 µM); also prevents calcium release from mitochondria induced by Ruthenium Red but not by uncouplers, respiratory inhibitors, or a chelating agent

Formal name: N-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dimethoxy-N-methyl-benzeneethanamine, monohydrochloride

Synonyms: 

Molecular weight: 395.9

CAS: 89805-39-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience

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