An inhibitor of Dkk1 that activates the Wnt signaling pathway

WAY-262611 – 5 mg

Brand:
Cayman
CAS:
1123231-07-1
Storage:
-20
UN-No:
Non-Hazardous - /

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{14336,13185,17947} Dickkopf-1 (Dkk1) antagonizes Wnt signaling and has important roles in bone formation, cancer, and Alzheimer’s disease.{30956} WAY-262611 is an inhibitor of Dkk1 that activates the Wnt signaling pathway, stimulating β-catenin/TCF-dependent transcription with an EC50 value of 0.63 µM.{30957} It has good pharmacokinetic properties and increases trabecular bone formation in ovariectomized rats following oral administration.{30957} WAY-262611 has been used to elucidate the role of Dkk1 in modulating Wnt signaling, particularly in the context of arthritis.{30955,30954}  

 

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Description

An inhibitor of Dkk1 that activates the Wnt signaling pathway, stimulating β-catenin/TCF-dependent transcription with an EC50 value of 0.63 µM; has good pharmacokinetic properties and increases trabecular bone formation in ovariectomized rats following oral administration

Formal name: 1-​[4-​(2-​naphthalenyl)​-​2-​pyrimidinyl]​-4-​piperidinemethanamin​e

Synonyms:  BML-WN110|Dickkopf-1 Inhibitor|Dkk1 Inhibitor

Molecular weight: 318.4

CAS: 1123231-07-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Signaling||Research Area|Cancer|Transcription Factors||Research Area|Cell Biology|Cell Signaling|Wnt Signaling||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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