An antihistamine that antagonizes the H1 receptor at high nanomolar concentrations; less potently blocks TRPC5 (IC50 = 1.0-1.3 µM)

Clemizole (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
1163-36-6
Storage:
-20
UN-No:
Non-Hazardous - /

Clemizole is an antihistamine that antagonizes the histamine 1 receptor at high nanomolar concentrations.{30958,30960} It less potently blocks transient receptor potential canonical channel 5 (TRPC5; IC50 = 1.0-1.3 µM), with at least 6-fold selectivity for TRPC5 over other TRP channels.{30962} Clemizole also has hepatitis C antiviral action through inhibition of NS4B function, showing synergy with boceprevir (Item No. 18379), and it inhibits seizures in a zebrafish model of Dravet Syndrome.{30961,30959}  

 

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Description

An antihistamine that antagonizes the H1 receptor at high nanomolar concentrations; less potently blocks TRPC5 (IC50 = 1.0-1.3 µM), with at least 6-fold selectivity for TRPC5 over other TRP channels

Formal name: 1-​[(4-​chlorophenyl)​methyl]​-​2-​(1-​pyrrolidinylmethyl)​-​1H-​benzimidazole, monohydrochloride

Synonyms:  AL 20|Allercur

Molecular weight: 362.3

CAS: 1163-36-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Allergy||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Neuroscience|Seizure Disorders

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