A synthetic agonist for GPR84 (EC50 = 512 nM); promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages; drives the recruitment of leukocytes and raises serum levels of CXCL1 (GRO-α) in vivo

6-OAU – 10 mg

Brand:
Cayman
CAS:
83797-69-7
Storage:
-20
UN-No:
Non-Hazardous - /

GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations.{27421} GPR84 is expressed in leukocytes and its expression is further induced by LPS.{27421,29190} 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM).{29190} It has insignificant actions at a panel of 69 other receptors, channels, or transporters.{29190} 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages.{29190} In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.{29190}  

 

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Description

A synthetic agonist for GPR84 (EC50 = 512 nM); promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages; drives the recruitment of leukocytes and raises serum levels of CXCL1 (GRO-α) in vivo

Formal name: 6-(octylamino)-2,4(1H,3H)-pyrimidinedione

Synonyms: 

Molecular weight: 239.3

CAS: 83797-69-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Innate Immunity

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