A cytotoxic compound that at 1 µM activates aryl hydrocarbon receptor signaling

5-fluoro 203 – 5 mg

Brand:
Cayman
CAS:
260443-89-8
Storage:
-20
UN-No:
Non-Hazardous - /

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. 5-fluoro 203 is a cytotoxic compound that at 1 µM activates AhR signaling, inducing transcription of CYP1A1, which leads to the formation of DNA adducts and cell cycle arrest.{28854,28853,27489} In certain ovarian, breast, kidney, and colorectal cancer cells, 5-fluoro 203 can increase the levels of reactive oxygen species as well as activate JNK, ERK, and p38 MAPK.{28855}  

 

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Description

A cytotoxic compound that at 1 µM activates aryl hydrocarbon receptor signaling, inducing transcription of cytochrome P450 1A1, which leads to the formation of DNA adducts and cell cycle arrest; can increase the levels of ROS as well as activate JNK, ERK, and p38MAPK in certain ovarian, breast, kidney, and colorectal cancer cells

Formal name: 4-(5-fluoro-2-benzothiazolyl)-2-methyl-benzenamine

Synonyms:  NSC 703786

Molecular weight: 258.3

CAS: 260443-89-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|DNA Damage and Repair||Research Area|Cell Biology|Cell Cycle||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Xenobiotic Sensing

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