A cell-permeable

Cdk4 Inhibitor – 1 mg

Brand:
Cayman
CAS:
546102-60-7
Storage:
-20
UN-No:
Non-Hazardous - /

Cdk4 inhibitor is a cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by blocking cyclin D1/Cdk4 with an IC50 value of 0.8 μM.{28945} It is selective for cyclin D1/Cdk4, demonstrating 7-fold and 28-fold weaker activity against cyclin E/Cdk2 and cyclin B/Cdk1, respectively, and little activity against calcium/calmodulin-dependent protein kinase II and protein kinase A.{28945} This compound has been shown to inhibit HCT116 and NCI-H460 tumor cell growth (IC50s 1 cell cycle arrest.{28945}  

 

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Description

A cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by selectively blocking cyclin D1/Cdk4 (IC50 = 0.8 μM); inhibits HCT116 and NCI-H460 tumor cell growth (IC50s 1 cell cycle arrest

Formal name: 2-bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

Synonyms:  Cyclin-dependent kinase 4 Inhibitor

Molecular weight: 404.2

CAS: 546102-60-7

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Signaling

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