An inhibitor of the yeast PITP Sec14

SMI-481 – 25 mg

Brand:
Cayman
CAS:
432020-20-7
Storage:
-20
UN-No:
Non-Hazardous - /

Phosphatidylinositol (PtdIns) transfer proteins (PITPs) mediate the exchange of PtdIns and phosphatidylcholine between membranes, a step required for a wide array of cellular processes including cell division. SMI-481 is an inhibitor of the yeast PITP Sec14, blocking both Sec14-mediated transfer of [3H]-PtdIns in vitro and growth (IC50s = 0.21 and 2.87 µM, respectively).{28675} Suppression of Sec14 expression leads to proportional reduction in SMI-481 inhibition, suggesting that SMI-481 acts specifically through Sec14.{28675} Moreover, SMI-481 does not affect [3H]-PtdIns transfer mediated by other yeast PITPs.{28675}  

 

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Description

An inhibitor of the yeast PITP Sec14, blocking both Sec14-mediated transfer of [3H]-PtdIns in vitro and growth (IC50s = 0.21 and 2.87 µM, respectively)

Formal name: (4-chloro-3-nitrophenyl)[4-(2-fluorophenyl)-1-piperazinyl]-methanone

Synonyms: 

Molecular weight: 363.8

CAS: 432020-20-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Lipid Biochemistry|Glycerophospholipids

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