A dual inhibitor of the two mammalian forms of PLD

ML-299 – 5 mg

Brand:
Cayman
CAS:
1426916-00-8
Storage:
-20
UN-No:
Non-Hazardous - /

ML-299 is a dual inhibitor of the two mammalian forms of phospholipase D (PLD), PLD1 and PLD2 (IC50s = 6 and 20 nM, respectively).{28737} It dose-dependently decreases the invasive migration of U98-MG glioblastoma cells into matrigel.{28737} ML-299 penetrates the central nervous system and is functional in vivo when given intraperitoneally.{28738} As PLD1 and PLD2 have roles in cancer and viral infection, ML-299 has potential applications in oncology and virology.{28738}  

 

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Description

A dual inhibitor of the two mammalian forms of PLD, PLD1 and PLD2 (IC50s = 6 and 20 nM, respectively); penetrates the CNS and is functional in vivo when given intraperitoneally; has potential applications in oncology and virology

Formal name: 4-bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]-benzamide

Synonyms:  CID 56593087

Molecular weight: 489.4

CAS: 1426916-00-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases

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