A highly sensitive peptide substrate for both human and mouse neutrophil elastase and PR3

MeOSuc-AAPV-pNA – 10 mg

Brand:
Cayman
CAS:
70967-90-7
Storage:
-20
UN-No:
Non-Hazardous - /

Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides.{28835} Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to destroy pathogens.{24588} Evaluating these enzymes is helpful to understanding inflammatory autoimmune processes. MeOSuc-AAPV-pNA is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3, but not cathepsin G or chymotrypsin.{28836,28837} Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm.  

 

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Description

A highly sensitive peptide substrate for both human and mouse neutrophil elastase and PR3

Formal name: N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-L-valinamide

Synonyms: 

Molecular weight: 590.6

CAS: 70967-90-7

Purity: ≥98%

Formulation: A crystalline solid

Application|Enzyme Activity||Product Type|Biochemicals|Labeling & Detection|Dyes, Stains, & Indicators||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Research Area|Immunology & Inflammation|Innate Immunity

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