A thyroid hormone that is about 1

3,3′,5′-Triiodo-L-thyronine – 10 mg

Brand:
Cayman
CAS:
5817-39-0
Storage:
-20
UN-No:
Non-Hazardous - /

3,3′,5’-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ than 3,3′,5-triiodo-L-thyronine (Item No. 16028) and commonly described as inactive.{28789,28791} However, high serum levels of rT3 are found in neonates and in certain conditions.{28795,28793,28790,28792} It reportedly activates TRΔα1, a native form of TRα that lacks a nuclear localization signal and functions in the cytoplasm.{28794} Through this action, rT3 initiates actin polymerization, particularly in astrocytes and neurons.{28794}  

 

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Description

A thyroid hormone that is about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ than T3; activates TRΔα1, a native form of TRα that lacks a nuclear localization signal and functions in the cytoplasm, initiating actin polymerization

Formal name: O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine

Synonyms:  3,3’,5’-T3|Reverse T3|rT3

Molecular weight: 651

CAS: 5817-39-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones

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