An ATP-competitive inhibitor of ATR (IC50 = 26 nM); augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions; sensitizes cancer cells to chemotherapy

VE-821 – 5 mg

Brand:
Cayman
CAS:
1232410-49-9
Storage:
-20
UN-No:
Non-Hazardous - /

Ataxia-telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. VE-821 is an ATP-competitive inhibitor of ATR (IC50 = 26 nM).{28657,28655} It augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions.{28655,28656,28658} VE-821 also sensitizes cancer cells to chemotherapy.{28656,28654,28573}  

 

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Description

An ATP-competitive inhibitor of ATR (IC50 = 26 nM); augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions; sensitizes cancer cells to chemotherapy

Formal name: 3-amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide

Synonyms:  ATR Inhibitor IV

Molecular weight: 368.4

CAS: 1232410-49-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling||Research Area|Cancer|DNA Damage and Repair

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