A cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM

EGFR/ErbB2 Inhibitor – 5 mg

Brand:
Cayman
CAS:
179248-61-4
Storage:
-20
UN-No:
Non-Hazardous - /

EGFR/ErbB2 inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (HER2, Neu; IC50s = 20 and 79 nM, respectively).{28556} It inhibits the proliferation of cancer cells overexpressing either c-ErbB2 or EGFR (IC50s = 2.3-2.5 µM).{28556} EGFR/ErbB2 inhibitor displays a high level of selectivity for these kinases.{28555}  

 

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Description

A cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively); inhibits the proliferation of cancer cells overexpressing either c-ErbB2 or EGFR (IC50s = 2.3-2.5 µM)

Formal name: 6,7-dimethoxy-N-[4-(phenylmethoxy)phenyl]-4-quinazolinamine

Synonyms: 

Molecular weight: 387.4

CAS: 179248-61-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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