A nonpeptidic antagonist of CCK1 (IC50 = 50 nM) that is 60-fold less effective at CCK2 (IC50 = 3 µM); blocks CCK-mediated gut muscle contraction

Lorglumide (sodium salt) – 5 mg

Brand:
Cayman
CAS:
1021868-76-7
Storage:
-20
UN-No:
Non-Hazardous - /

Cholecystokinin (CCK) is a peptide hormone that, through specific receptors, induces pancreatic growth and enzyme secretion, smooth muscle contraction in the gall bladder and stomach, and modulates feeding and behavior.{16813,16024,16665} Lorglumide is a nonpeptidic antagonist of the CCK A receptor (CCK1; IC50 = 50 nM) that is 60-fold less effective at the CCK B receptor (CCK2; IC50 = 3 µM).{28711} It blocks CCK-mediated gut muscle contraction, pancreatic growth, and pancreatic secretion.{28708,28712,28713} Lorglumide is commonly used to study the roles of CCK1 in tissues and in animals.{28709,28710}  

 

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Description

A nonpeptidic antagonist of CCK1 (IC50 = 50 nM) that is 60-fold less effective at CCK2 (IC50 = 3 µM); blocks CCK-mediated gut muscle contraction, pancreatic growth, and pancreatic secretion; commonly used to study the roles of CCK1 in tissues and in animals

Formal name: 4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoic acid, monosodium salt

Synonyms: 

Molecular weight: 481.4

CAS: 1021868-76-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area

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