An ATP-competitive inhibitor of JNK1

JNK Inhibitor V – 1 mg

Brand:
Cayman
CAS:
345987-15-7
Storage:
-20
UN-No:
Non-Hazardous - /

c-Jun N-terminal kinases (JNKs) phosphorylate c-Jun and regulate transcription in response to an array of inflammatory signals.{14317} JNK inhibitor V is an ATP-competitive inhibitor of JNK1, JNK2, and JNK3 (IC50s = 150, 220, and 70 nM, respectively).{28600,28598} While initial studies demonstrated 10- to 100-fold selectivity for JNK isoforms over a panel of 25 other kinases, strong interactions of JNK inhibitor V with GSK3B, Pim-1, Pim-3, and other kinases, evaluated as a shift in thermal melting point, suggest additional targets exist.{28600,23658} In vivo efficacy of JNK inhibitor V against JNK isoforms has been demonstrated in gerbils, mice, and rats via oral, intravenous, or intraperitoneal administration.{23658,28599} This compound is commonly used to investigate the role of JNK signaling in cells and animals.{28601,28602}  

 

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Description

An ATP-competitive inhibitor of JNK1, JNK2, and JNK3 (IC50s = 150, 220, and 70 nM, respectively); effective in vivo in gerbils, mice, and rats via oral, intravenous, or intraperitoneal administration

Formal name: a-[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]-2-benzothiazoleacetonitrile

Synonyms:  AS-601245|c-Jun N-terminal Kinase Inhibitor V

Molecular weight: 372.5

CAS: 345987-15-7

Purity: ≥98% (sum of isomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|JNK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling

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