A benzimidazole that selectively disrupts the activity of IRAK 1 and 4 (IC50 = 0.3 and 0.2 µM

IRAK-1/4 Inhibitor – 1 mg

Brand:
Cayman
CAS:
509093-47-4
Storage:
-20
UN-No:
Non-Hazardous - /

Interleukin-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. Dysregulation of TIR signaling, typified by increased NF-κB activity, results in the development of some cancers and other diseases, making the development of IRAK inhibitors a potential therapeutic strategy. IRAK-1/4 inhibitor is a benzimidazole that disrupts the activity of IRAK-1 and -4 with IC50 values of 0.3 and 0.2 µM, respectively.{29157} It demonstrates IC50 values >10 µM in a panel of 27 other kinases tested.{29157} This compound has been used to inhibit a pro-inflammatory response in microglia isolated from clinically diagnosed Alzheimer’s disease patients.{29158}  

 

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Description

A benzimidazole that selectively disrupts the activity of IRAK 1 and 4 (IC50 = 0.3 and 0.2 µM, respectively)

Formal name: N-[1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitro-benzamide

Synonyms: 

Molecular weight: 395.4

CAS: 509093-47-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition

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