An L-type calcium channel inhibitor; induces relaxation of precontracted isolated porcine coronary artery segments (EC50 = 0.15 nM); selective for L-type calcium channels over N-

(±)-Felodipine – 5 mg

Brand:
Cayman
CAS:
72509-76-3
Storage:
-20
UN-No:
Non-Hazardous - /

Felodipine is an inhibitor of L-type calcium channels.{28544} It induces relaxation of precontracted isolated porcine coronary artery segments (EC50 = 0.15 nM), which highly express L-type calcium channels.{53284} (±)-Felodipine is selective for L-type calcium channels over N-, R-, and P/Q-type channels at 10 µM, as well as the T-type Cav3.2 channel (IC50 = 6.8 µM).{28544,28732} (±)-Felodipine preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 33.9 and 3,981 nM, respectively).{28545} It decreases mean arterial blood pressure and total peripheral resistance in a rabbit model of hypertension induced by renal artery ligation when administered intravenously at doses of 30 and 100 nmol/kg.{53285}  

 

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Description

An L-type calcium channel inhibitor; induces relaxation of precontracted isolated porcine coronary artery segments (EC50 = 0.15 nM); selective for L-type calcium channels over N-, R-, and P/Q-type channels at 10 µM, as well as the T-type Cav3.2 channel (IC50 = 6.8 µM); inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 33.9 and 3,981 nM, respectively); decreases mean arterial blood pressure and total peripheral resistance in a rabbit model of hypertension induced by renal artery ligation at 30 and 100 nmol/kg

Formal name: 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester

Synonyms:  H 154/82

Molecular weight: 384.3

CAS: 72509-76-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease

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