Description
An L-type calcium channel inhibitor; induces relaxation of precontracted isolated porcine coronary artery segments (EC50 = 0.15 nM); selective for L-type calcium channels over N-, R-, and P/Q-type channels at 10 µM, as well as the T-type Cav3.2 channel (IC50 = 6.8 µM); inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 33.9 and 3,981 nM, respectively); decreases mean arterial blood pressure and total peripheral resistance in a rabbit model of hypertension induced by renal artery ligation at 30 and 100 nmol/kg
Formal name: 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester
Synonyms: H 154/82
Molecular weight: 384.3
CAS: 72509-76-3
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease