A structural analog of NAADP that blocks NAADP-dependent calcium release (IC50 = 6 nM) as well as NAADP binding to sea urchin egg homogenate (IC50 = 0.4 nM); does not affect either IP3-mediated calcium release or cyclic ADP-ribose-mediated calcium release

trans-Ned-19 – 10 mg

Brand:
Cayman
CAS:
1354235-96-3
Storage:
-20
UN-No:
Non-Hazardous - /

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a dinucleotide second messenger that triggers the release of calcium from lysosomes and related cellular compartments.{28523} trans-Ned-19 is a structural analog of NAADP that blocks NAADP-dependent calcium release (IC50 = 6 nM) as well as NAADP binding to sea urchin egg homogenate (IC50 = 0.4 nM).{28527} The trans form of Ned-19 is significantly more potent than the cis isomer in both assays.{28527} Ned-19 does not affect either IP3-mediated calcium release or cyclic ADP-ribose-mediated calcium release.{28527} It directly binds NAADP receptors on lysosomes in mouse pancreatic beta cells and competitively antagonizes activation by NAADP.{28527,28526} It inhibits glucose-induced calcium oscillations in pancreatic islets and insulin-induced calcium increases in 3T3-L1 adipocytes.{28527,28525} Ned-19 also blocks calcium signaling induced by endothelin-1 or norepinephrine in renal afferent arterioles.{28424} Ned-19 dose-dependently reduces infection of host cells by Ebola virus.{28524}  

 

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Description

A structural analog of NAADP that blocks NAADP-dependent calcium release (IC50 = 6 nM) as well as NAADP binding to sea urchin egg homogenate (IC50 = 0.4 nM); does not affect either IP3-mediated calcium release or cyclic ADP-ribose-mediated calcium release

Formal name: (1R,3S)-1-[3-[[4-(2-fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Synonyms: 

Molecular weight: 514.6

CAS: 1354235-96-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Ebola

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