A cell-permeable

Bisindolylmaleimide X (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
145317-11-9
Storage:
-20
UN-No:
Non-Hazardous - /

Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).{17342} It has been shown to inhibit PKCα, βI, βII, γ, and ε with IC50 values of 8, 8, 14, 13, and 39 nM, respectively.{17342} It has also been identified as an inhibitor of Cdk2 (IC50 = 200 nM) and GSK3α/β.{28472} This compound has been used to activate mesenchymal stem cells, increase the surface expression of homing ligands that bind to intercellular adhesion molecule 1, and target delivery of these cells to sites of inflammation.{28473}  

 

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Description

A cell-permeable, reversible, ATP-competitive PKC inhibitor (IC50 = 15 nM, rat brain PKC); inhibits PKCα, βI, βII, γ, and ε with IC50 values of 8, 8, 14, 13, and 39 nM, respectively; also inhibits Cdk2 (IC50 = 200 nM) and GSK3α/β; used to activate mesenchymal stem cells and target their delivery to sites of inflammation

Formal name: 3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, monohydrochloride

Synonyms:  BIM X|Ro 31-8425

Molecular weight: 461

CAS: 145317-11-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Signaling||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Cell Biology|Stem Cell Research||Research Area|Immunology & Inflammation

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