An inactive control for the selective PAD4 inhibitors

GSK106 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
1652591-82-6
Storage:
-20
UN-No:
Non-Hazardous - /

Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases.{18134} GSK106 is an inactive control for the selective PAD4 inhibitors, GSK484 (Item No. 17488) and GSK199 (Item No. 17489).{28376} It does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils (IC50s > 100 µM).{28376} See the Structural Genomics Consortium (SGC) website for more information on both GSK484 and GSK106.  

 

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Description

An inactive control for the selective PAD4 inhibitors, GSK484 and GSK199 (IC50s >100 µM)

Formal name: (3-amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanone, monohydrochloride

Synonyms: 

Molecular weight: 438

CAS: 1652591-82-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Negative Controls||Research Area|Epigenetics, Transcription, & Translation|Writers|Citrullination||Research Area|Immunology & Inflammation|Innate Immunity|NETosis

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