A fluorogenic substrate that can be cleaved specifically by caspase-8

Ac-IETD-AFC – 1 mg

Brand:
Cayman
CAS:
211990-57-7
Storage:
-20
UN-No:
Non-Hazardous - /

Ac-IETD-AFC is a fluorogenic substrate that can be cleaved by caspase-8 and related enzymes that recognize the amino acid sequence IETD, including caspase-3 processing enzyme, caspase-10, and granzyme B.{28649} Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.  

 

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Description

A fluorogenic substrate that can be cleaved specifically by caspase-8, caspase-3 processing enzyme, caspase-10, and granzyme B

Formal name: N-acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine

Synonyms:  N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin

Molecular weight: 729.7

CAS: 211990-57-7

Purity: ≥95%

Formulation: A crystalline solid

Application|Enzyme Activity||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area

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