A prenylflavonoid with potent estrogenic activity that inhibits both ERα and ERβ (IC50s = 57 and 68 nM

(±)-8-Prenylnaringenin – 1 mg

Brand:
Cayman
CAS:
68682-02-0
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-8-Prenylnaringenin ((±)-8-PN) is a prenylflavonoid with potent estrogenic activity that can be isolated from hops.{29600,29598} It inhibits both isoforms of the human estrogen receptor (ER; IC50s = 57 and 68 nM for ERα and ERβ, respectively).{29601} (±)-8-PN is effective in vivo, suppressing loss of bone mineral density in ovariectomized rats and blocking changes in tail skin temperature in a rat model of postmenopausal hot flashes.{29599}  

 

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Description

A prenylflavonoid with potent estrogenic activity that inhibits both ERα and ERβ (IC50s = 57 and 68 nM, respectively); effective in vivo, suppressing bone loss and temperature changes in rat models of osteoporosis and postmenopausal hot flashes

Formal name: 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one

Synonyms:  (±)-8-PN

Molecular weight: 340.4

CAS: 68682-02-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Phytosterols||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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