An in vitro inhibitor of reverse transcriptases from retroviruses

2′,3′-Dideoxyadenosine 5′-triphosphate – 100 µL

Brand:
Cayman
CAS:
24027-80-3
Storage:
-20
UN-No:
Non-Hazardous - /

2′,3′-Dideoxyadenosine 5′-triphosphate (ddATP) is an in vitro inhibitor of reverse transcriptases from retroviruses, including HIV-1 and visna (Kis = 20 and 37 nM, respectively).{28262,28268,28264} It also blocks, in vitro, mammalian and bacterial DNA polymerases.{28265,28263} ddATP, produced intracellularly by the phosphorylation of exogenously supplied 2’,3’-dideoxyadenosine, competes with dATP, resulting in chain termination.{28265,28263} Because of this activity, dideoxynucleoside 5’-triphosphates, including ddATP, are used to terminate chain extension produced by the Taq polymerase used in polymerase chain reactions.{28266} It is also an antagonist of the purinergic receptor P2X2/3 (pIC50 = 6.5).{28267}  

 

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Description

An in vitro inhibitor of reverse transcriptases from retroviruses, including HIV-1 and visna (Kis = 20 and 37 nM, respectively); also blocks, in vitro, mammalian and bacterial DNA polymerases

Formal name: 2′,3′-dideoxy-adenosine 5′-(tetrahydrogen triphosphate)

Synonyms:  ddATP

Molecular weight: 475.2

CAS: 24027-80-3

Purity: ≥99%

Formulation: A clear aqueous solution

Product Type|Biochemicals|Antivirals|Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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