A cytotoxic illudin that is converted

Illudin S – 5 mg

Brand:
Cayman
CAS:
1149-99-1
Storage:
-20
UN-No:
Non-Hazardous - /

Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential.{28238,28236} Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM).{28238} T-lymphocyte leukemia CEM cells that are resistant to doxorubicin (Item No. 15007), epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S.{28238} Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.{28236,28237,28239}  

 

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Description

A cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM)

Formal name: (2’S,3’R,6’R)-2′,3′-dihydro-3′,6′-dihydroxy-2′-(hydroxymethyl)-2′,4′,6′-trimethyl-spiro[cyclopropane-1,5′-[5H]inden]-7′(6’H)-one

Synonyms:  Lampterol|NSC 400979|NSC 626369

Molecular weight: 264.3

CAS: 1149-99-1

Purity: ≥98%

Formulation: A light yellow solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|DNA Damage and Repair

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