A multi-kinase inhibitor; inhibits growth and induces apoptosis in Ba/F3 and AML cell lines expressing constitutively active FLT3 (IC50s = 150-650 nM) but not those expressing TEL-ABL

SU 5614 – 5 mg

Brand:
Cayman
CAS:
1055412-47-9
Storage:
-20
UN-No:
Non-Hazardous - /

SU 5614 is a chlorinated derivative of SU 5416 (Item No. 13342) and a multi-kinase inhibitor.{37298} It inhibits growth and induces apoptosis in Ba/F3 and acute myeloid leukemia (AML) cell lines expressing constitutively active FLT3 (IC50s = 150-650 nM) but not those expressing TEL-ABL, TEL-JAK2, or BCR-ABL (IC50s = >10 μM). SU 5614 also inhibits C-KIT, VEGFR, and PDGFRβ in vitro (IC50s = 0.03, 0.46, and 0.36 μM, respectively).  

 

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Description

A multi-kinase inhibitor; inhibits growth and induces apoptosis in Ba/F3 and AML cell lines expressing constitutively active FLT3 (IC50s = 150-650 nM) but not those expressing TEL-ABL, TEL-JAK2, or BCR-ABL (IC50s = >10 μM); inhibits C-KIT, VEGFR, and PDGFRβ in vitro (IC50s = 0.03, 0.46, and 0.36 μM, respectively)

Formal name: (3Z)-5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one

Synonyms: 

Molecular weight: 272.7

CAS: 1055412-47-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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