Description
A multi-kinase inhibitor; inhibits growth and induces apoptosis in Ba/F3 and AML cell lines expressing constitutively active FLT3 (IC50s = 150-650 nM) but not those expressing TEL-ABL, TEL-JAK2, or BCR-ABL (IC50s = >10 μM); inhibits C-KIT, VEGFR, and PDGFRβ in vitro (IC50s = 0.03, 0.46, and 0.36 μM, respectively)
Formal name: (3Z)-5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
Synonyms:
Molecular weight: 272.7
CAS: 1055412-47-9
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling
