A potent

A-66 – 5 mg

Brand:
Cayman
CAS:
1166227-08-2
Storage:
-20
UN-No:
Non-Hazardous - /

A-66 is a potent, selective inhibitor of the PI3K isoform p110α (IC50 = 32 nM in a cell-free assay).{32579} It displays over 100-fold selectivity for p110α over other isoforms. A-66 is effective in vivo, suppressing the growth of SK-OV-3 tumor xenografts in mice.{32579} It also impairs all measures of in vivo insulin action in mice.{32580} A-66 partially suppresses B cell receptor-dependent Akt activation and proliferation.{31648}  

 

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Description

A potent, selective inhibitor of the PI3K isoform p110α (IC50 = 32 nM in a cell-free assay); suppresses the growth of SK-OV-3 tumor xenografts and impairs all measures of in vivo insulin action in mice

Formal name: (2S)-N1-[2-(1,1-dimethylethyl)-4′-methyl[4,5′-bithiazol]-2′-yl]-1,2-pyrrolidinedicarboxamide

Synonyms: 

Molecular weight: 393.5

CAS: 1166227-08-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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