A potent

AZD 2014 – 25 mg

Brand:
Cayman
CAS:
1009298-59-2
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 2014 is a potent, selective, ATP-competitive mTORC1/2 dual inhibitor that inhibits phosphorylation of both mTORC1 and 2 substrate proteins in whole cells.{33186} It exhibits an IC50 value of 2.81 nM against the isolated recombinant enzyme and >1,000-fold selectivity against all PI3K isoforms.{33186} AZD 2014 has broad antiproliferative effects across multiple cell lines and reduces tumor growth in in vivo models of ER+ breast cancer.{33186}. It has efficacy against acute myeloid leukemia when combined with the pan Pim kinase inhibitor AZD 1208 (Item No. 20235) and enhances the radiosensitivity of different cancer cell types.{32019,33187,33188}  

 

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Description

A potent, selective, ATP-competitive mTORC1/2 dual inhibitor (IC50 = 2.81 nM against the isolated recombinant enzyme); exhibits >1,000-fold selectivity against all PI3K isoforms; has broad antiproliferative effects across multiple cell lines, reduces tumor growth in in vivo models of ER+ breast cancer, and acts as a radiosensitizer

Formal name: 3-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-N-methyl-benzamide

Synonyms:  Vistusertib

Molecular weight: 462.5

CAS: 1009298-59-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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