An inhibitor of the IRE1/XBP1 pathway

STF-083010 – 10 mg

Brand:
Cayman
CAS:
307543-71-1
Storage:
-20
UN-No:
Non-Hazardous - /

STF-083010 is an inhibitor of the IRE1/XBP1 pathway, blocking IRE1 endonuclease activity without affecting its kinase activity after endoplasmic reticulum (ER) stress both in vitro and in vivo.{32110} STF-083010 (60 µM) reduces the splicing of XBP1 by IRE1 in the presence of thapsigargin (Item No. 10522), an ER stress inducer.{32110} This has cytotoxic effects against multiple myeloma cells and drives apoptosis in pancreatic cancer cells.{32110,31589}  

 

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Description

An inhibitor of the IRE1/XBP1 pathway, blocking IRE1 endonuclease activity without affecting its kinase activity after ER stress both in vitro and in vivo; has cytotoxic effects against multiple myeloma cells and drives apoptosis in pancreatic cancer cells

Formal name: N-[(2-hydroxy-naphthalenyl)methylene]-2-thiophenesulfonamide

Synonyms:  IRE1 Inhibitor I

Molecular weight: 317.4

CAS: 307543-71-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking

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