A 2-thiazolylhydrazone derivative that

Remodelin – 5 mg

Brand:
Cayman
CAS:
949912-58-7
Storage:
-20
UN-No:
Non-Hazardous - /

Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 µM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria.{26026} Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules.{26026} Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10.{26026} Remodelin also has cytotoxic effects against some species of the fungus Candida.{25935}  

 

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Description

A 2-thiazolylhydrazone derivative that, at 10 µM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria; inhibits NAT10

Formal name: 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile

Synonyms: 

Molecular weight: 282.4

CAS: 949912-58-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetyltransferases||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Neuroscience

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