Oxcarbazepine – 250 mg

Brand:
Cayman
CAS:
28721-07-5
Storage:
-20
UN-No:
Non-Hazardous - /

Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Item No. 18467).{25311,45753} It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM.{45753} Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or picrotoxin (Item No. 20771) in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.  

 

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Description

,A prodrug form of 10,11-dihydro-10-hydroxy carbamazepine; inhibits high-frequency repetitive firing of rat spinal cord neurons at 1 µM; protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20 mg/kg), as well as PTZ- or picrotoxin-induced seizures in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively)

Formal name: 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide

Synonyms:  GP47680

Molecular weight: 252.3

CAS: 28721-07-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Neuroscience|Seizure Disorders

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