A PDE4 inhibitor (Kis = 3.4 µM in human bronchus and polymorphonuclear leukocytes) that produces bronchodilator and anti-inflammatory effects; blocks L-type Ca2+-channels in smooth muscle

Glaucine – 5 mg

Brand:
Cayman
CAS:
475-81-0
Storage:
-20
UN-No:
Non-Hazardous - /

Glaucine is an alkaloid originally isolated from G. flavum that demonstrates antitussive properties.{28311} It is structurally related to papaverine (Item No. 10011133), a non-selective phosphodiesterase (PDE) inhibitor. Glaucine selectively inhibits PDE4 (Kis = 3.4 µM in human bronchus and polymorphonuclear leukocytes).{28311} It has been shown to have bronchodilation and anti-inflammatory effects, inhibiting the spontaneous and histamine-induced tone in human isolated bronchus and augmenting cyclic AMP accumulation.{28311} Glaucine also binds to the benzothiazepine site on L-type Ca2+-channels in smooth muscle, blocking calcium ion signaling.{28311} This compound has been detected as a recreational drug capable of eliciting dissociative effects.{20293}  

 

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Description

A PDE4 inhibitor (Kis = 3.4 µM in human bronchus and polymorphonuclear leukocytes) that produces bronchodilator and anti-inflammatory effects; blocks L-type Ca2+-channels in smooth muscle

Formal name: (6aS)-5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline

Synonyms:  NSC 34396

Molecular weight: 355.4

CAS: 475-81-0

Purity: ≥95%

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Drugs of Abuse||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Forensic Chemistry & Toxicology

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