A substrate-selective p38α MAPK inhibitor; selectively inhibits p38α-dependent phosphorylation of MK2 over ATF2 (Kiapps = 330 and >20

MK2a Inhibitor – 10 mg

Brand:
Cayman
CAS:
41179-33-3
Storage:
-20
UN-No:
Non-Hazardous - /

MK2a inhibitor is a substrate-selective inhibitor of p38α MAPK that selectively inhibits p38α-dependent phosphorylation of MAPKAPK-2 (MK2) over activating transcription factor 2 (ATF2; Kiapps = 330 and >20,000 nM, respectively, in cell-free assays).{46548} It inhibits proliferation of U87, A172, and U251 glioblastoma cells (EC50s = 0.6-1 μM) via inhibition of tubulin polymerization and induction of apoptosis.{46549}  

 

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Description

A substrate-selective p38α MAPK inhibitor; selectively inhibits p38α-dependent phosphorylation of MK2 over ATF2 (Kiapps = 330 and >20,000 nM, respectively, in cell-free assays); inhibits proliferation of U87, A172, and U251 glioblastoma cells (EC50s = 0.6-1 μM) via inhibition of tubulin polymerization and induction of apoptosis

Formal name: 2′-fluoro-N-(4-hydroxyphenyl)-[1,1′-biphenyl]-4-butanamide

Synonyms:  CMPD 1

Molecular weight: 349.4

CAS: 41179-33-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|p38 MAPK||Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p38 MAPK Signaling||Research Area|Cell Biology

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