An α2-adrenergic receptor antagonist (Kd = 2.6 µM) and an L-type calcium channel blocker (IC50 = 17 µM) well-known for its coronary vasodilator effects; inhibits K-Ras plasma membrane localization (IC50 = 9.64 µM)

Fendiline (hydrochloride) – 1 g

Brand:
Cayman
CAS:
13636-18-5
Storage:
-20
UN-No:
Non-Hazardous - /

Fendiline is an α2-adrenergic receptor antagonist (Kd = 2.6 µM) and an L-type calcium channel blocker (IC50 = 17 µM) well-known for its coronary vasodilator effects.{28339,28340,28341,28338} Fendiline has recently been reported to inhibit K-Ras plasma membrane localization (IC50 = 9.64 µM), which prevents K-Ras signal transduction and blocks the proliferation of K-Ras-transformed tumor cells.{28342}  

 

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Description

An α2-adrenergic receptor antagonist (Kd = 2.6 µM) and an L-type calcium channel blocker (IC50 = 17 µM) well-known for its coronary vasodilator effects; inhibits K-Ras plasma membrane localization (IC50 = 9.64 µM), blocking the proliferation of K-Ras-transformed tumor cells

Formal name: γ-phenyl-N-(1-phenylethyl)-benzenepropanamine, monohydrochloride

Synonyms: 

Molecular weight: 351.9

CAS: 13636-18-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Signaling|GTPases||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization

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