A TRPV4 agonist that has been reported to elicit calcium influx in HEK cells expressing mouse or human TRPV4 (EC50s = 18 and 2.1 nM

GSK1016790A – 5 mg

Brand:
Cayman
CAS:
942206-85-1
Storage:
-20
UN-No:
Non-Hazardous - /

Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel thought to be involved in osmoregulation, hyperalgesia, and control of epithelial cell volume. GSK1016790A is a TRPV4 agonist that has been reported to elicit calcium influx in HEK cells expressing mouse or human TRPV4 (EC50s = 18 and 2.1 nM, respectively).{28187} It has been used to demonstrate a role for TRPV4 in regulating urinary bladder activity and endothelial control of vascular tone.{28187,28188,28189}  

 

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Description

A TRPV4 agonist that has been reported to elicit calcium influx in HEK cells expressing mouse or human TRPV4 (EC50s = 18 and 2.1 nM, respectively); used to demonstrate a role for TRPV4 in regulating urinary bladder activity and endothelial control of vascular tone

Formal name: N-[(1S)-1-[[4-[(2S)-2-[[(2,4-dichlorophenyl)sulfonyl]amino]-3-hydroxy-1-oxopropyl]-1-piperazinyl]carbonyl]-3-methylbutyl]-benzo[b]thiophene-2-carboxamide

Synonyms: 

Molecular weight: 655.6

CAS: 942206-85-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Neuroscience

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