A full agonist of the serotonin 5-HT7 receptor (Ki = 0.22 nM) that displays 200- and greater than 1

LP44 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
824958-12-5
Storage:
-20
UN-No:
Non-Hazardous - /

LP44 is a full agonist of the serotonin 5-HT7 receptor (Ki = 0.22 nM) that displays 200- and greater than 1,000-fold selectivity over 5-HT1A (Ki = 52.7 nM) and 5-HT2A (Ki = 326 nM) receptors, respectively.{28320} It can induce relaxation of substance P-induced guinea pig ileum contraction with an EC50 value of 2.56 μM.{28320}  

 

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Description

A full agonist of the serotonin 5-HT7 receptor (Ki = 0.22 nM) that displays 200- and greater than 1,000-fold selectivity over 5-HT1A (Ki = 52.7 nM) and 5-HT2A (Ki = 326 nM) receptors, respectively; induces relaxation of substance P-induced guinea pig ileum contraction with an EC50 value of 2.56 μM

Formal name: 4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide, monohydrochloride

Synonyms: 

Molecular weight: 488.1

CAS: 824958-12-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience

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