An orally active inhibitor of sPLA2-IIA; protects against intestinal reperfusion injury in rats when given at 10 mg/kg orally; attenuates NF-κB signaling in lung cancer cells and protects against diet-induced metabolic syndrome in rats

sPLA2 Inhibitor – 5 mg

Brand:
Cayman
CAS:
393569-31-8
Storage:
-20
UN-No:
Non-Hazardous - /

Secreted phospholipases A2 (sPLA2s) are a diverse family of low molecular weight PLA2s with tissue-specific expression patterns and actions.{23479} The group IIA sPLA2 (sPLA2-IIA) was originally purified from platelets and exudates from patients with rheumatoid arthritis.{23479} Its expression can be induced by inflammatory mediators, and mouse studies suggest that it may play roles in colorectal polyposis, atherosclerosis, and bacterial infections.{23479,23478} sPLA2 inhibitor is an orally active inhibitor of sPLA2-IIA.{28309} It protects against intestinal reperfusion injury in rats when given at 10 mg/kg orally.{28309} sPLA2 inhibitor also attenuates NF-κB signaling in lung cancer cells and protects against diet-induced metabolic syndrome in rats.{28310,28308}  

 

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Description

An orally active inhibitor of sPLA2-IIA; protects against intestinal reperfusion injury in rats when given at 10 mg/kg orally; attenuates NF-κB signaling in lung cancer cells and protects against diet-induced metabolic syndrome in rats

Formal name: γS-[(1-oxo-7-phenylheptyl)amino]-4-(phenylmethoxy)-benzenepentanoic acid

Synonyms:  KH064|Secretory Phospholipase A2 Inhibitor

Molecular weight: 487.6

CAS: 393569-31-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Metabolic Syndrome||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases

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