Description
A taurine-conjugated form of lithocholic acid; increases caspase-3 and -7 activity in NTCP-transfected Hep3B cells at 75 µM; has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis; serum levels of TLCA increase approximately 5-fold in within two hours during an oral lipid tolerance test in humans
Formal name: 2-[[(3α,5β)-3-hydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt
Synonyms: NSC 681057|Sodium taurolithocholate|TLCA
Molecular weight: 505.7
CAS: 6042-32-6
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome