An inhibitor of tBid (Kd = 20 µM)

BI-6C9 – 1 mg

Brand:
Cayman
CAS:
791835-21-7
Storage:
-20
UN-No:
Non-Hazardous - /

BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis.{28610,28613} BI-6C9 is an inhibitor of tBid (Kd = 20 µM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria.{28607,28608} It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation.{28611,28609} BI-6C9 (10 µM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.{28612}  

 

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Description

An inhibitor of tBid (Kd = 20 µM), blocking the release of both cytochrome c and Smac from mitochondria; prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation; inhibits the nuclear translocation of AIF, preventing the death of OVCAR-3 cells induced by IFN-α2a

Formal name: N-[4-[(4-aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-butanamide

Synonyms: 

Molecular weight: 471.6

CAS: 791835-21-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology

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