A reversible

IC261 – 1 mg

Brand:
Cayman
CAS:
186611-52-9
Storage:
-20
UN-No:
Non-Hazardous - /

IC261 is a reversible, ATP-competitive inhibitor of casein kinase 1 (CK1) that inhibits CK1δ and CK1ɛ (IC50 = ~1 µM for both), as well as CK1α (IC50 = 16 µM).{28923} It is at least 100-fold less effective against PKA, p34cdc2, and p55fyn.{28923} IC 261, at 1 µM, inhibits cytokinesis in primary mouse embryo fibroblasts.{28921} IC261 is used to elucidate the role of CK1 in cells and in whole organisms.{28925,28924,28922}  

 

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Description

A reversible, ATP-competitive inhibitor of CK1δ and CK1ɛ (IC50 = ~1 µM for both), as well as CK1α (IC50 = 16 µM); at 1 µM, inhibits cytokinesis in primary mouse embryo fibroblasts; used to elucidate the role of CK1 in cells and in whole organisms

Formal name: 1,3-dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one

Synonyms:  SU5607

Molecular weight: 311.3

CAS: 186611-52-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CK1||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Cycle

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