An inhibitor of Hsp70 (IC50 = 0.5 µM) that is selective over Hsp90; binds the NBDs of Hsc70 (Ki = 10 µM) and Grp78 (KD = 80 nM); inhibits the proliferation of human breast and colon cancer cell lines

VER-155008 – 50 mg

Brand:
Cayman
CAS:
1134156-31-2
Storage:
-20
UN-No:
Non-Hazardous - /

VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 µM) that is selective over Hsp90.{28942} It targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 µM) and glucose-regulated protein 78 (Grp78; KD = 80 nM).{28941,28939} VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death.{28940} It induces the proteasome-dependent degradation of Hsp90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors.{28942,28940} VER-15508 also triggers paraptosis in anaplastic thyroid carcinoma cells.{28938}  

 

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Description

An inhibitor of Hsp70 (IC50 = 0.5 µM) that is selective over Hsp90; binds the NBDs of Hsc70 (Ki = 10 µM) and Grp78 (KD = 80 nM); inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death

Formal name: 5′-O-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

Synonyms: 

Molecular weight: 556.4

CAS: 1134156-31-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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