Description
An alkaloid with anticancer and antitussive activities; binds to tubulin and induces cell cycle arrest at the G2/M phase in HeLa cells at 20 µM; induces apoptosis in HeLa cells and thymocytes (IC50s = 25 and 10 µM, respectively) and reduces proliferation of MCF-7 breast and Renal 1983 bladder cancer cells (IC50s = 42.3 and 39.1 µM, respectively); induces tumor regression in an MCF-7 mouse xenograft model at 120 mg/kg; decreases the number of citric acid-induced coughs in guinea pigs at 30 and 70 mg/kg e
Formal name: (3S)-6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone, monohydrochloride
Synonyms: Narcotine|Opianine
Molecular weight: 449.9
CAS: 912-60-7
Purity: ≥98%
Formulation: A crystalline solid
Application||Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Adaptive Immunity