An inhibitor of glucosylceramide synthase; inhibits glucosylceramide synthase by 70

DL-threo-PPMP (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
139974-41-7
Storage:
-20
UN-No:
Non-Hazardous - /

DL-threo-PPMP is a ceramide analog and an inhibitor of glucosylceramide synthase.{11391} It inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, when used at a concentration of 20 µM. DL-threo-PPMP also inhibits sphingomyelin synthase activity in erythrocytes infected with P. falciparum and inhibits late ring-stage P. falciparum growth (IC50 = 0.85 µM).{48898} It reduces Akt and ribosomal protein S6 phosphorylation in HEK293 cells and increases autophagy flux in primary mouse neurons.{28272} [Matreya, LLC. Catalog No. 1720]  

 

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Description

An inhibitor of glucosylceramide synthase; inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, at 20 µM; inhibits sphingomyelin synthase activity in P. falciparum-infected erythrocytes and inhibits growth of P. falciparum (IC50 = 0.85 µM)

Formal name: rel-N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-hexadecanamide, monohydrochloride

Synonyms:  DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol

Molecular weight: 511.2

CAS: 139974-41-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience

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