A topoisomerase I inhibitor that is cytotoxic to HT-29 cells (IC50 = 19 nM)

9-amino Camptothecin – 10 mg

Brand:
Cayman
CAS:
91421-43-1
Storage:
-20
UN-No:
Non-Hazardous - /

DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways.{21116} 9-amino Camptothecin is a topoisomerase I inhibitor that was developed as a more water-soluble analog of camptothecin (Item No. 11694).{21114,21115} It is cytotoxic to HT-29 cells at an IC50 value of 19 nM, induces DNA damage in whole cells at a concentration of 85 nM, and demonstrates significant anti-tumor activity in clinical studies.{21114,21115}  

 

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Description

A topoisomerase I inhibitor that is cytotoxic to HT-29 cells (IC50 = 19 nM), induces DNA damage in whole cells (at 85 nM), and demonstrates significant anti-tumor activity

Formal name: (4S)-10-amino-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Synonyms:  NSC 603071

Molecular weight: 363.4

CAS: 91421-43-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|Topoisomerase

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