A bacterial second messenger and cyclic dinucleotide; an important second messenger in bacteria involved in biofilm formation

Cyclic di-GMP (sodium salt) – 1 mg

Brand:
Cayman
CAS:
2222132-40-1
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclic di-GMP is a second messenger in bacteria involved in diverse prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling.{28201,28203} In eukaryotic cells, cyclic di-GMP is detected by and binds to the transmembrane protein stimulator of interferon genes (STING; Kd = 1.21 µM), leading to activation of the innate immune system.{28202,29220} It has been used at a preset molar ratio with STING dimers in binding assays to determine the binding constants of particularly tight binding partners, such as 2’3’-cGAMP. Cyclic di-GMP induces IFN-β mRNA expression in vitro (EC50 = 537.8 nM) but less potently than 2’3’-cGAMP (Item No. 19887), 3’2’-cGAMP, 3’3’-cGAMP (Item No. 17966), and 2’2’-cGAMP (Item No. 22419).  

 

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Description

A bacterial second messenger and cyclic dinucleotide; an important second messenger in bacteria involved in biofilm formation, motility, virulence, and cell cycling; detected by and binds to STING in eukaryotic cells, activating the innate immune system (Kd = 1.21 µM); induces IFN-β mRNA expression in vitro (EC50 = 537.8 nM) less potently than other cyclic dinucleotides

Formal name: guanylyl-(3’→5′)-3′-guanylic acid, cyclic nucleotide, disodium salt

Synonyms:  3′,5′-Cyclic diguanylic acid|c-di-GMP|Cyclic diguanylate

Molecular weight: 734.4

CAS: 2222132-40-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Activators||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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