An analog of cAMP that super-activates Epacs (AC50 = 1.8 µM)

8-pCPT-2′-O-Me-Cyclic AMP (sodium salt) – 5 mg

Brand:
Cayman
CAS:
634207-53-7
Storage:
-20
UN-No:
Non-Hazardous - /

Exchange proteins activated by cAMP (Epacs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2.{23361} 8-pCPT-2′-O-Me-Cyclic AMP is an 8-(4-chlorophenylthio) analog of cAMP that activates Epacs (AC50 = 1.8 µM).{28115} It is a super-activator of Epacs in that it dissociates GDP from Rap1 more strongly than the natural Epac agonist, cAMP.{28115,28118} 8-pCPT-2′-O-Me-cAMP is strongly selective for Epac over the cAMP-activated kinase PKA.{28118} It does not discriminate between Epac1 and Epac2 and is used extensively to elucidate the roles of these Rap GEFs in cell function.{23361,28116,28117,23348}  

 

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Description

An analog of cAMP that super-activates Epacs (AC50 = 1.8 µM), dissociating GDP from Rap1 more strongly than the natural Epac agonist, cAMP; strongly selective for EPac over PKA

Formal name: ​8-[(4-chlorophenyl)thio]-2′-O-methyl-adenosine cyclic 3′,5′-(hydrogen phosphate)​, monosodium salt

Synonyms:  8-CPT-2Me-cAMP|8-pCPT-cAMP|8-pCPT-2′-O-Me-cAMP

Molecular weight: 507.8

CAS: 634207-53-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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